Fold-Up Containment Device For Bone Defects

ABSTRACT

A bone graft system includes a two-dimensional mesh sheet sized and shaped to, when folded along fold lines, form a three-dimensional graft containment structure configured to be packed with a bone graft material for placement within a target area of a bone, the mesh sheet including a first end flap connected to a remaining portion of the mesh sheet via a first fold line and a second end flap connected to the remaining portion of the mesh sheet via a second fold line, a third fold line extending from the first fold line to the second fold line so that the remaining portion is configured to be wrapped around folded first and second end flaps to form the graft containment structure, the first and second end flaps substantially corresponding to a profile of the target area of the bone.

PRIORITY CLAIM

The present application claims priority to U.S. Provisional PatentApplication Serial No. 62/417,052 filed on Nov. 3, 2016. The entiredisclosure of the above application is expressly incorporated herein byreference.

BACKGROUND

Mandible defects are often treated with bone grafts and/or implants suchas, bone plates, to assist with healing. The bone grafts may be placedin the target area using any of a variety of methods. However, without acontainer for the bone graft, the graft may fall away from a target sitebefore it can be incorporated by the body into the healing bone.

SUMMARY

The present disclosure is directed to a bone graft system comprising atwo-dimensional mesh sheet sized and shaped to, when folded along foldlines, form a three-dimensional graft containment structure configuredto be packed with a bone graft material for placement within a targetarea of a bone, the mesh sheet including a first end flap connected to aremaining portion of the mesh sheet via a first fold line and a secondend flap connected to the remaining portion of the mesh sheet via asecond fold line, a third fold line extending from the first fold lineto the second fold line so that the remaining portion is configured tobe wrapped around folded first and second end flaps to form the graftcontainment structure, the first and second end flaps substantiallycorresponding to a profile of the target area of the bone.

The present disclosure is also directed to a bone graft systemcomprising a graft containment assembly including a plurality oftwo-dimensional mesh sheets connected to one another along longitudinaledges thereof, each of the mesh sheets sized and shaped so that, whenfolded along fold lines, each of the mesh sheets form athree-dimensional graft containment structure configured to be packedwith a bone graft material, each graft containment structure movablerelative to an adjacent graft containment structure to form a desiredconfiguration of the graft containment assembly for placement of thegraft containment assembly within a target area of a bone.

The present disclosure also relates to a method for treating a bonecomprising folding a first two-dimensional mesh sheet along fold linesto form a first three-dimensional graft containment structure, the firstmesh sheet including a first end flap connected to a remaining portionof the mesh sheet via a first fold line and a second end flap connectedto the remaining portion of the mesh sheet via a second fold line, athird fold line extending from the first fold line to the second foldline so that the remaining portion is configured to be wrapped aroundfolded first and second end flaps to form the first graft containmentstructure, packing the first graft containment structure with a bonegraft material, maintaining the first graft containment structure in aclosed configuration, so that the bone graft material is heldtherewithin, positioning the first graft containment structure within atarget area of a bone, and fixing the first graft containment structureto the bone.

BRIEF DESCRIPTION

FIG. 1 shows a top plan view of a system according to an exemplaryembodiment of the present disclosure;

FIG. 2 shows a perspective view of the system of FIG. 1;

FIG. 3 shows another perspective view of the system of FIG. 1;

FIG. 4 shows a perspective view of the system of FIG. 1, in a foldedconfiguration;

FIG. 5 shows a top plan view of a system according to another exemplaryembodiment of the present disclosure;

FIG. 6 shows a perspective view of the system of FIG. 5, in a foldedconfiguration;

FIG. 7 shows a perspective view of a system according to yet anotherexemplary embodiment of the present disclosure;

FIG. 8 shows a perspective view of a mesh sheet according to the systemof FIG. 7;

FIG. 9 shows a top plan view of the system of FIG. 7, in a foldedconfiguration and positioned in a target area of a bone;

FIG. 10 shows a perspective view of the system FIG. 7, in a foldedconfiguration and positioned in the target area of the bone; and

FIG. 11 shows a cross-sectional side view of a graft containmentstructure according to the system of FIG. 7.

DETAILED DESCRIPTION

The present invention may be understood with reference to the followingdescription and the appended drawings, wherein like elements arereferred to with the same reference numerals. The present inventionrelates to the treatment of bone and, in particular, relates totreatments using bone grafts and bone graft substitutes. Exemplaryembodiments of the present invention describe a graft containment cageconfigured to be positioned in a gap or space in a target bone (e.g.,the mandible) so that graft material may be packed therein to encourageand guide the generation of new bone in the gap/space. In one exemplaryembodiment, the cage may be positioned between two separated portions ofbone to generate new bone joining the separated portions of bone. Itwill be understood by those of skill in the art, however, that the graftcontainment cage may be inserted or positioned within any gap or spaceof the target bone including, for example, at an end of the bone, sothat there is bone only on one side of the graft containment cage, orwithin a recessed space of the bone, so that three sides of the graftcontainment cage contact bone. The graft containment device of theexemplary embodiment is formed as a two-dimensional mesh sheet that issized and shaped to be folded-up into a three-dimensional structure thathas a shape that substantially corresponds to a shape of a recess orspace that is to be filled. Bone graft material or a bone graftsubstitute material may be packed inside the three-dimensionalstructure. In one embodiment, the graft containment device is sized,shaped and structure to treat defects of the mandible. Although theexemplary embodiment is shown and described as being used in treating amandible, it will be understood by those of skill in the art that thegraft containment device of the present invention may also be formed indifferent shapes and sized to permit use in treating other types of bonewhich would benefit from the use of a graft containment device.

As shown in FIGS. 1-4, a system 100 according to an exemplary embodimentof the present disclosure comprises a two-dimensional mesh sheet 102sized and shaped to be folded along fold lines 106, as shown in FIG. 1,to form a three-dimensional graft containment structure 104, as shown inFIG. 4, that is configured to be inserted into a target area of a bone(e.g., to replace a portion of a mandible). The mesh sheet 102 isspecifically sized and shaped so that, when folded, the graftcontainment structure 104 may be positioned in a target area—e.g., aspace formerly occupied by bone that has been resected. The target areamay, for example, be located ends of a bone on either side of a portionof bone that has been removed. Each of the ends of the graft containmentstructure 104 may substantially correspond to a profile of an outersurface of a corresponding one of the ends of the separated portions ofbone so that the graft containment structure 104 bridges the twoseparated portions of the bone. Graft material may be packed within aninterior of the graft containment structure 104 to promote bone growthbetween the separated portions of bone as would be understood by thoseskilled in the art.

The mesh sheet 102, as shown in FIG. 1, includes a plurality of foldlines 106 along which the mesh sheet 102 is specifically configured tobe folded to form the graft containment structure 104, as shown in FIG.4. The mesh sheet 102 defines a first surface 122 which, when the meshsheet 102 is folded into the graft containment structure 104, forms aninterior of the graft containment structure 104, and a second surface124 which, when the mesh sheet 102 is folded into the graft containmentstructure 104, forms an exterior of the graft containment structure 104.The mesh sheet 102 also defines a first edge 108 and an opposing secondedge 110 such that, when the mesh sheet 102 is folded along the foldlines 106, the resulting graft containment structure 104 extends along alongitudinal axis from a first end 112 corresponding to the first edge108 to a second end 114 corresponding to the second edge 110. The foldlines 106 may be formed as, for example, living hinges, facilitatingfolding of the mesh sheet 102 therealong.

In one embodiment, the mesh sheet 102 includes at least three-fold lines106 which divide the mesh sheet 102 into segments defining distinctsurfaces of the graft containment structure 104. The mesh sheet 102 maybe shaped to include a first end flap 116 and a second end flap 118,each of which is connected to a remaining portion 120 of the mesh sheet102 via one of the fold lines 106. In particular, the first end flap 116is connected to the remaining portion 120 of the mesh sheet 102 via afirst one of the fold lines 106 a and the second end flap 118 isconnected to the remaining portion 120 via a second one of the foldlines 106 b. The first and second end flaps 116, 118 may be folded alongthe first and second fold lines 106 a, 106 b, respectively, toward thefirst surface 122. When folded, the first and second end flaps 116, 118extend transverse to the longitudinal axis of the graft containmentstructure 104 to define first and second ends 112, 114, respectively, ofthe graft containment structure 104. In one example, the first andsecond end flaps 116, 118 fold to extend substantially perpendicular tothe longitudinal axis of the graft containment structure 104. As wouldbe understood by those skilled in the art, a shape of each of the firstand second end flaps 116, 118 may generally be formed to correspond to aprofile of an outer surface of the separated portions of bone.

A third one of the fold lines 106 c extends from the first edge 108 tothe second edge 110 and connects the first and second fold lines 106 a,106 b. Thus, upon folding the mesh sheet 102 along the first and secondfold lines 106 a, 106 b, the mesh sheet 102 may be folded along thethird fold line 106 c (FIG. 2) and the remaining portion 120 may bewrapped around the folded first and second end flaps 116, 118 (FIG. 3)so that the first surface 122 extends about a perimeter of the first andsecond end flaps 116, 118, in contact with edges 130, 132, respectively,thereof, to form a substantially closed space within the containmentstructure 104 (FIG. 4) in which graft material may be held. As would beunderstood by those of skill in the art the graft containment structure104 may be filled with graft material during or before folding of themesh sheet 102. The graft containment structure 104 may be maintained inthe closed configuration in any of a variety of ways. For example, thegraft containment structure 104 may be closed via suturing and/orhooking.

In a further embodiment, the mesh sheet 102 includes an overlappingportion 126 connected to the remaining portion 120 of the mesh sheet 102via a fourth fold line 106 d. When folded along the fourth fold line,the overlapping portion 126 overlaps a portion of the remaining portion120 to facilitate closing of the graft containment structure 104. Thisoverlapping portion 126 may be sutured or otherwise attached to theremaining portion 120 to maintain the graft containment structure 104 inthe closed configuration, thereby holding the graft material therein.

The mesh sheet 102 may be shaped so that, in one embodiment, uponcompletion of the folding process, the graft containment structure 104includes an overhang 128 at each of the first and second ends 112, 114.In other words, a portion of the mesh sheet 102 may extend beyond eachof the folded first and second flaps 116, 118 so that, when the graftcontainment structure 104 is positioned in the target area of the bone,the overhang 128 extends over ends of the separated portions of bone.The overhang 128 may be affixed to the bone via, for example, a bonefixation element, to fix the graft containment structure 104 relative tothe bone.

The mesh sheet 102 may be manufactured in a variety of shapes and sizesso that a surgeon or other user may select a desired size and shape mostsuitable for treating a target bone. In addition or alternatively, asurgeon or other user may trim the mesh sheet 102 to achieve a graftcontainment structure 104 better suited for the portion of the targetbone being treated. For example, portions of the overhang 128 and/or thefirst and second end flaps 116, 118 may be trimmed to achieve a desiredfit. The mesh sheet 102 may include trim lines in the form of, forexample, split lines, to guide the proper trimming thereof

The mesh sheet 102 may be formed of materials such as resorbablepolymers (e.g., PCL) or non-resorbable polymers, metals (e.g., titanium)or composites (e.g., graphene, elastomer), depending on an anatomicalregion being treated and an indication. The mesh sheet 102 may include aplurality of pores extending through the material thereof, the poresshaped to promote vascularization of the bone while preventing graftmaterial packed in the graft containment structure 104 from fallingthereoutof. The pores may also be sized and shaped to receive a fixationelement therein. In one example, the pores may be sized to receive afixation screw having a 1.8 mm diameter. In another embodiment, the meshsheet 102 may be formed via a plurality of intersecting struts formed ofa desired material, the struts intersecting to define the pores.

According to an exemplary method, the mesh sheet 102 is configured to befolded along fold lines 106 to form the graft containment structure 104.In particular, the first and second end flaps 116, 118 are foldedinward, toward the first surface 122 until the first and second endflaps 116, 118 are substantially perpendicular with respect to theremaining portion 120 of the mesh sheet 102. The remaining portion 120is wrapped around a perimeter of the first and second end flaps 116, 118so that the first surface 122 contacts the edges 130, 132 of the firstand second flaps, respectively. If so desired, the mesh sheet 102 may betrimmed prior to folding of the mesh sheet 102 to better suit the targetarea of the bone being treated. Graft material may be packed into thegraft containment structure 104 as the mesh sheet 102 is being foldedinto the desired shape. Once folding of the mesh sheet 102 has beencompleted, the graft containment structure 104 forms a substantiallyclosed space in which the graft material is held, preventing the graftmaterial from falling thereoutof. Edges and/or surfaces of the meshsheet 102 which are brought into contact with one another to form thegraft containment structure 104 may be sutured, hooked or otherwiseaffixed to maintain the shape of the graft containment structure.

Once the graft containment structure 104 is in the desired shape and ispacked with graft material, as desired, the graft containment structure104 may be placed in a desired positioned in a recess or gap between twoportions of the target bone. For example, the graft containmentstructure 104 may be positioned such that the first and second ends 112,114 of the graft containment structure 104 are substantially inalignment with ends separated portions of the bone. The graftcontainment structure 104 may be further trimmed, if so desired, to aidin positioning of the graft containment structure 104 in the target areaof the bone. In one embodiment, overhangs 128 at the first and secondends 112, 114 of the grail containment structure 104 may overlap theends of the separated portions of bone. These overhangs 128 may be fixedto the bone via, for example, bone fixation elements such as bonescrews. The graft containment structure 104 may also be fixed to thebone via a bone plate, extending along a length of the graft containmentstructure 104 so that ends of the bone plate extend over ends of theseparated portions of bone. The bone plate may be fixed both to thegraft containment structure 104 and to the bone.

Although the exemplary embodiment describes using a single graftcontainment structure 104 to treat the target area, multiple graftcontainment structures 104 may be utilized to treat the target area.This may, however, require trimming of the mesh sheets 102 and/or graftcontainment structures 104 to fit the target area. In one embodiment,the graft containment structures 104 may be attached to one another, endto end, to form a desired length and/or curvature useful for treatingthe target area.

According to another exemplary embodiment, as shown in FIGS. 5 and 6, asystem 200 may be substantially similar to the system 100 describedabove, comprising a mesh sheet 202 configured to be folded along foldlines 206 a, 206 b to form a graft containment structure 204. The graftcontainment structure 204, however, may be specifically designed using athree-dimensional digital environment to match a patient's specific bonedimensions, which may be obtained via, for example, 3D imaging of atarget bone. In particular, the 3D scan may be used to generate desireddimensions of the graft containment structure 204 such as, for example,length, curvature, and cross-sectional area. These dimensions are usedto design a virtual 3D shape which may then be translated to a digitaltwo-dimensional design to construct a patient-specific mesh sheet 202.The system 200 may use the mesh sheet 102 of the system 100 as atwo-dimensional template for the mesh sheet 202. Using the desireddimensions of the graft containment structure 204 and the mesh template,the patient-specific mesh sheet 202 is constructed. The mesh sheet 202is specifically sized and shaped according to the desired dimensions andis formed to include fold lines 206 a, 206 b such that, when foldedalong fold lines 206 a, 206 b, a graft containment structure 204 havingthe desired dimensions is formed.

The mesh sheet 202 may be substantially similar to the mesh sheet 102described above in regard to the system 100. The mesh sheet 202 mayinclude curved longitudinal edges 234, 236 and opposing first and secondlateral edges 208, 210 which taper relative to one another as theyextend from a first one of the longitudinal edges 234 toward a secondone of the longitudinal edges 236. The mesh sheet 202 may also includeadditional fold lines 206 a, 206 b and slits 238 along portions thereofto achieve, when folded, a desired curvature and shape of the graftcontainment structure 204.

In one embodiment, the mesh sheet 202 is particularly constructed totreat a patient's mandible. Similarly to the mesh sheet 102, the meshsheet 202 includes a first end flap 216 and a second end flap 218 which,when folded, define first and second ends 212, 214, respectively, of thegraft containment structure 204. The first and second end flaps 216, 218are specifically sized and shaped to correspond to a profile of thetarget area of the mandible of the patient. Longitudinally extendingfold lines 206 a are designed so that, when folded therealong, theresulting graft containment structure 204 has the desiredcross-sectional area for treating the target area of the patient'smandible. The mesh sheet 202 further includes slits 238 extendingtherealong in alignment with a portion laterally extending fold lines206 b so that, when folded, adjacent portions 240 of the mesh sheet 202,separated from one another via the laterally extending fold lines 206 b,may be bent relative to one another to achieve the desired curvature ofthe graft containment structure 204.

Similarly to the mesh sheet 102, the mesh sheet 202 may also be shapedso that, when folded, the graft containment structure 204 includesoverhangs 228 extending beyond the folded first and second end flaps216, 218. The overhangs 228 may extend over ends of the separatedportions of the bone so that the graft containment structure 204 may befixed to the bone via these overhangs 228.

The system 200 may be utilized in substantially the same manner asdescribed above with respect to the system 100. In particular, the meshsheet 202 may be folded along fold lines 206 a, 206 b to construct thepatient-specific graft containment structure 204. The graft containmentstructure 204 may be packed with graft material during the folding ofthe mesh sheet 202. As described above, the graft containment structure204 will have a desired size, cross-sectional shape and curvature fortreating the target area of the patient.

As shown in FIGS. 7-11, a system 300 may be substantially similar to thesystems 100, 200 described above. The system 300, however, comprises agraft containment assembly 301 including a plurality of mesh sheets 302connected to one another along first longitudinal edges 334 thereof, asshown in FIG. 7. Each of the mesh sheets 302 may be substantiallysimilar to the mesh sheets 102, 202, and may be individually folded toform graft containment structures 304 which, together, form a graftcontainment device 303 for treating a target area of a patient's bone.Since the mesh sheets 302 are connected along the first longitudinaledges 334, upon folding of the mesh sheets 302, each of the resultinggraft containment structures 304 may be positioned/oriented with respectto one another to obtain a desired curvature of the assembly 301 to fita target area of a bone. Similarly to the system 200, the system 300 maybe specifically designed using a three dimensional digital environmentto match a patient's specific bone dimensions, which may be obtainedvia, for example, 3D imaging of a target bone. In particular, the 3Dscan may be used to generate desired dimensions of the graft containmentassembly 301 such as, for example, length, curvature, andcross-sectional area. These dimensions are then translated to a digitaltwo-dimensional design to construct patient-specific mesh sheet 302,which may be folded to form the desired assembly of graft containmentstructures 304. Alternatively, the system 300 or any of the embodimentsdescribed, may be made in standard sizes which a physician may trim,bend or otherwise customize to suit individual patients in any knownmanner(s).

Each of the mesh sheets 302, as shown in FIG. 8, may be substantiallysimilar to the mesh sheet 102, described above in regard to the system100. Each mesh sheet 302 is two-dimensional and is defined via a firstsurface 322 which, when the mesh sheet 302 is folded toward the graftcontainment structure 304 forms an interior of the graft containmentstructure 304, and a second surface 324 which, when the mesh sheet 302is folded toward the graft containment structure 304 forms an exteriorof the graft containment structure. Each mesh sheet 302 may be furtherdefined via first and second longitudinal edges 334, 336 and first andsecond lateral edges 108, 110. Similarly to the mesh sheet 102, eachmesh sheet 302 is sized and shaped to be folded along fold lines 306 toform a desired graft containment structure 304 of the graft containmentassembly 301. Each of the graft containment structures 304 may be filledwith graft material so that the graft containment assembly 301 may beplaced within the target area to promote bone growth and healing. Inparticular, each mesh sheet 302 a first end flap 316 and a second endflap 318 connected to a remaining portion 320 of each mesh sheet 302 viaa first fold line 306 a and a second fold line 306 b, respectively. Whenthe mesh sheet 302 is folded, the first and second end flaps 316, 318may form first and second ends 312, 314, respectively, of the graftcontainment structure 304.

The mesh sheet 302 may include a third fold line 306 c along which theremaining portion 320 may be folded to wrap the remaining portion 320about a perimeter of the first and second end flaps 316, 318. The meshsheet 302 may be folded to form the graft containment structure 304 insubstantially the same was as described above for the system 100. Graftmaterial may be packed within each of the graft containment structures304 of the assembly 301 during the folding process. Although theexemplary embodiment shows and describes three-fold lines 306, it willbe understood by those of skill in the art that the mesh sheets 302 mayinclude more than three-fold lines 306 to form, for example, overlappingportions, similarly to the mesh sheet 102.

It will be understood by those of skill in the art that each of the meshsheets 302 may have varying sizes and shapes so that a cross-sectionalarea of the assembly 301 may have a varying size and shape along alength thereof to mimic a naturally changing profile of the bone (e.g.,mandible). In particular, first and second end flaps 316, 318 of each ofthe mesh sheets 302 may vary in size and shape so that the resultinggraft containment structures 304 may establish a desired profile withinthe target area.

Once each of the mesh sheets 302 have been folded and packed with grailmaterial, the graft containment assembly 301 may be positioned, asdesired, within the target area of the bone, as shown in FIGS. 9 and 10.Since the mesh sheets 302 are connected to one another along the firstlongitudinal edges 334, the formed graft containment structures 304 maybe positioned and/or oriented with respect to one another (e.g., angled)to form a desired configuration (e.g., curvature) of the assembly 301suitable for treating the target area. The graft containment assemblymay be affixed to separated ends of the bone via, for example, anoverhang 328 extending from a first one of the mesh sheets 302 a and alast one of the mesh sheets 302 b to extend over the separated ends ofthe bone when the assembly 301 is positioned therein. As shown in FIG.10, the system 300 may further comprise an implant such as, for example,a bone plate 340 for providing additional fixation. The bone plate 340may extend across the graft containment structures 304 such that ends342, 344 thereof extend along the ends of the separated portions ofbone. The bone plate 340 may be fixed to each of the graft containmentstructures 304 to maintain adjacent graft containment structures 304 ina desired position/orientation relative to one another.

As shown in FIG. 11, in a further embodiment, the graft containmentstructures 304 may be formed with grooves 346 sized and shaped toreceive the bone plate 340 therein so that, when the bone plate 340 isplaced within the grooves 346 of the graft containment structures 304,the bone plate 340 prevents relative movement between the bone plate 340and the bone graft containment structures 304 and relative movementbetween the bone graft containment structures 304 of the assembly 301.In one embodiment, the grooves 346 may be formed via additional foldlines 306 extending along the mesh sheets 302.

It will be understood by those of skill in the art that modificationsand variations may be made in the structure and methodology of thepresent invention, without departing from the spirit or the scope of theinvention. Thus, it is intended that the present invention cover themodifications and variations of this invention, provided that they comewithin the scope of the appended claims and their equivalents.

What is claimed is:
 1. A bone graft system, comprising: atwo-dimensional mesh sheet sized and shaped to, when folded along foldlines, form a three-dimensional graft containment structure configuredto be packed with a bone graft material for placement within a targetarea of a bone, the mesh sheet including a first end flap connected to aremaining portion of the mesh sheet via a first fold line and a secondend flap connected to the remaining portion of the mesh sheet via asecond fold line, a third fold line extending from the first fold lineto the second fold line so that the remaining portion is configured tobe wrapped around folded first and second end flaps to form the graftcontainment structure, the first and second end flaps substantiallycorresponding to a profile of the target area of the bone.
 2. The systemof claim 1, wherein the mesh sheet comprises an overlapping portionconnected to the remaining portion of the mesh sheet via a fourth foldline.
 3. The system of claim 1, wherein, when the mesh sheet is foldedto form the three-dimensional graft containment structure, one of afirst end and a second end of the graft containment structure include anoverhang extending beyond one of the folded first and second end flaps.4. The system of claim 3, the overhang configured to extend over aportion of bone to fix the graft containment structure thereto.
 5. Thesystem of claim 4, the overhang including an opening extendingtherethrough, the opening sized and shaped for receiving a bone fixationelement therethrough.
 6. The system of claim 1, wherein the mesh sheetis formed via a plurality of pores extending therethrough.
 7. The systemof claim 6, wherein the mesh sheet is formed via a plurality ofintersecting struts, the intersecting struts defining the plurality ofpores.
 8. The system of claim 1, wherein first and second longitudinaledges of the mesh sheet extend along a curve and include intersectinglongitudinal fold lines and lateral fold lines.
 9. The system of claim8, wherein a portion of the lateral fold lines include a slit extendingtherealong so that, when folded, the bone graft containment structureextends along a curve corresponding to a curvature of a patient'smandible.
 10. A bone graft system, comprising: a graft containmentassembly including a plurality of two-dimensional mesh sheets connectedto one another along longitudinal edges thereof, each of the mesh sheetssized and shaped so that, when folded along fold lines, each of the meshsheets form a three-dimensional graft containment structure configuredto be packed with a bone graft material, each graft containmentstructure movable relative to an adjacent graft containment structure toform a desired configuration of the graft containment assembly forplacement of the graft containment assembly within a target area of abone.
 11. The system of claim 10, wherein each of the mesh sheetsincludes a first end flap connected to a remaining portion of the meshsheet via a first fold line and a second end flap connected to theremaining portion of the mesh sheet via a second fold line, a third foldline extending from the first fold line to the second fold line so thatthe remaining portion is configured to be wrapped around folded firstand second end flaps to form the graft containment structure, the firstand second end flaps substantially corresponding to a profile of thetarget area of the bone.
 12. The system of claim 10, wherein a size andshape of each of the mesh sheets may vary so that a cross-sectional areaof the graft containment structures may vary along a length of the graftcontainment assembly.
 13. The system of claim 10, wherein one of a firstmesh sheet at a first end of the graft containment assembly and a secondmesh sheet at a second end of the graft containment assembly includes anoverhang so that, when the graft containment assembly is positionedwithin the target area, the overhang extends over a portion of the bone.14. The system of claim 10, further comprising a bone plate configuredto be positioned over a length of the graft containment assembly to fixadjacent bone graft containment structured relative to one another. 15.The system of claim 14, wherein, when the mesh sheets are folded to formgraft containment structures, each of the graft containment structuresinclude a groove extending therein, the groove sized and shaped toreceive the bone plate.
 16. A method for treating a bone, comprising:folding a first two-dimensional mesh sheet along fold lines to form afirst three-dimensional graft containment structure, the first meshsheet including a first end flap connected to a remaining portion of themesh sheet via a first fold line and a second end flap connected to theremaining portion of the mesh sheet via a second fold line, a third foldline extending from the first fold line to the second fold line so thatthe remaining portion is configured to be wrapped around folded firstand second end flaps to form the first graft containment structure;packing the first graft containment structure with a bone graftmaterial; maintaining the first graft containment structure in a closedconfiguration, so that the bone graft material is held therewithin;positioning the first graft containment structure within a target areaof a bone; and fixing the first graft containment structure to the bone.17. The method of claim 16, wherein maintaining the first graftcontainment structure in the closed configuration includes one ofsuturing and hooking longitudinal edges of the first graft containmentstructure together.
 18. The method of claim 16, further comprisingfolding a second two-dimensional mesh sheet along fold lines to form asecond three-dimensional graft containment structure, the second meshsheet including a first end flap connected to a remaining portion of themesh sheet via a first fold line and a second end flap connected to theremaining portion of the mesh sheet via a second fold line, a third foldline extending from the first fold line to the second fold line so thatthe remaining portion is configured to be wrapped around folded firstand second end flaps to form the second graft containment structure, thefirst and second mesh sheets connected to one another along longitudinaledges thereof so that the first and second graft containment structuresare movable relative to one another.
 19. The method of claim 18, furthercomprising attaching a bone plate to each of the first and second graftcontainment structures and to a portion of bone over which an end of thebone plate extends.
 20. The method of claim 16, further comprisingfixing the first graft containment structure to the bone by inserting abone fixation element through an overhang extending from the first graftcontainment structure to extend over a portion of bone.
 21. The methodof claim 16, wherein the first two-dimensional mesh sheet is designedusing a virtual three-dimensional shape based on a patient's specificbone dimensions.
 22. The method of claim 21, wherein the patient'sspecific bone dimensions are obtained from a 3D image of the patient'sbone.